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End-use stage means the use of a substance as such or in a mixture by professional workers widespread uses , by consumers or at industrial sites , a last step before the end-of-life of the substance, namely before the substance is consumed in a process by reaction during use including intermediate use , is emitted to waste streams or the environment or is included into an article. It corresponds to activities taking place at industrial sites. Precautionary measures and safe use This section provides information on the recommended measures to minimise or prevent adverse effects resulting from exposure to a hazardous product, or improper storage or handling of a hazardous product.

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Mneimneh, Saad Chromosomal crossover is a biological mechanism to combine parental traits. It is perhaps the first mechanism ever taught in any introductory biology class. The formulation of crossover, and resulting recombination, came about years after Mendel's famous experiments.

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To a great extent, this formulation is consistent with the basic genetic findings of Mendel. More importantly, it provides a mathematical insight for his two laws and corrects them.

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From a mathematical perspective, and while it retains similarities, genetic recombination guarantees diversity so that we do not rapidly converge to the same being. It is this diversity that made the study of biology possible.

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In particular, the problem of genetic mapping and linkage-one of the first efforts towards a computational approach to biology-relies heavily on the mathematical foundation of crossover and recombination. Nevertheless, as students we often overlook the mathematics of these phenomena.

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Emphasizing the mathematical aspect of Mendel's laws through crossover and recombination will prepare the students to make an early realization that biology, in addition to being experimental, IS a computational science.

This can serve as a first step towards a broader curricular transformation in teaching biological sciences.

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I will show that a simple and modern treatment of Mendel's laws using a Markov chain will make this step possible, and it will only require basic college-level probability and calculus. My personal teaching experience confirms that students WANT to know Markov chains because they hear about them from bioinformaticists all the time. This entire exposition is based on three homework problems that I designed for a course in computational biology.

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A typical reader is, therefore, an instructional staff member or a student in a computational field e. However, other students may easily follow by omitting the Directory of Open Access Journals Sweden Saad Mneimneh Full Bb genetics high fat burner iii Available Chromosomal crossover is a biological mechanism to combine parental traits. However, other students may easily follow by.

For more information on total tonnage band calculation please consult the Data submission manual. Additionally, if available, information on the use of the substance and how consumers and workers are likely to be exposed to it can also be displayed here. The information is aggregated from REACH registered dossiers provided by industry through a use descriptor system based on five separate descriptor lists which in combination with each other form a brief description of use and exposure for certain life cycle stage. The use information is displayed per relevant life cycle stage of the substance. Manufacture stage includes processes by which the substance is manufactured from raw materials.