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We conclude that BDNF produced by Merkel cells during a precise embryonic period guides SAI neuron development, providing the first direct evidence that the skin instructs sensory neuron molecular and functional maturation. Merkel cell ablation also decreased downstream TrkB signaling in DRGs, and altered the expression of genes associated with SAI development and function. Uptake of U and As was also observed in fish from the lake with maximum bioconcentration factors for liver of 1.

Dr. Drauzio Varella explica os efeitos das fórmulas para emagrecer.

The Kadji Sai U legacy site represents a source of contamination of the local environment by naturally occurring radionuclides and associated trace elements. In addition to in situ gamma and Rn dose rate measurements, sampling included at site fractionation of water and sampling of water, fish, sediment, soils and vegetation.

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The concentrations of radionuclides and trace metals in water from Issyk-Kul Lake were in general low, but surprisingly high for As. Uptake of U and As was also observed in fish from the lake with maximum bioconcentration factors for liver of 1. The concentrations of U in water within the Kadji Sai area varied from 0.

Uranium concentrations in the drinking water of Kadji Sai village were about the level recommended by the WHO for drinking water. Uranium, As and Ni were mainly present as low molecular mass LMM, less than 10 kDa species in all samples, indicating that these elemental species are mobile and potentially bioavailable.

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The soils from the mining sites were enriched in U, As and trace metals. Hot spots with elevated radioactivity levels were easily detected in Kadji Sai and radioactive particles were observed.

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The presence of particles carrying significant amount of.